The Biology of Human Immunodeficiency Virus‐1 IIIB Infection in the Chimpanzee: In Vivo and In Vitro Correlations
- 1 June 1989
- journal article
- Published by Wiley in Journal of Medical Primatology
- Vol. 18 (3-4) , 343-355
- https://doi.org/10.1111/j.1600-0684.1989.tb00237.x
Abstract
Human immunodeficiency virus (HIV)-1 IIIB infection of chimpanzees leads to a compartmentalized, nonpathogenic in vivo and in vitro relationship with the virus. The absence of an acquired immunodeficiency syndrome (AIDS)-like disease in over 100 chimpanzees persistently infected may be related to some or all of the findings reported here. Further characterizing these possible host adapative mechanisms may be critical in both understanding pathogenesis, as well as elucidating novel mechanisms for therapeutic and/or the preventive strategies for AIDS in humans.Keywords
This publication has 20 references indexed in Scilit:
- Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes.The Journal of Experimental Medicine, 1988
- Seropositivity for HIV and the development of AIDS or AIDS related condition: three year follow up of the San Francisco General Hospital cohortBMJ, 1988
- HIV infection of primate lymphocytes and conservation of the CD4 receptorNature, 1987
- Simple, Rapid, Quantitative, Syncytium-Forming Microassay for the Detection of Human Immunodeficiency Virus Neutralizing AntibodyAIDS Research and Human Retroviruses, 1987
- CD8 + Lymphocytes Can Control HIV Infection in Vitro by Suppressing Virus ReplicationScience, 1986
- Vaginal Transmission of Human Immunodeficiency Virus (HIV) to a ChimpanzeeThe Journal of Infectious Diseases, 1986
- The Role of Mononuclear Phagocytes in HTLV-III/LAV InfectionScience, 1986
- INFECTION OF CHIMPANZEES BY HUMAN T-LYMPHOTROPIC RETROVIRUSES IN BRAIN AND OTHER TISSUES FROM AIDS PATIENTSThe Lancet, 1985
- INFECTION OF CHIMPANZEES WITH LYMPHADENOPATHY-ASSOCIATED VIRUSThe Lancet, 1984
- Transmission of HTLV-III Infection from Human Plasma to Chimpanzees: An Animal Model for AIDSScience, 1984