Transmission of HTLV-III Infection from Human Plasma to Chimpanzees: An Animal Model for AIDS
- 2 November 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 226 (4674) , 549-552
- https://doi.org/10.1126/science.6093251
Abstract
Two of three chimpanzees given plasma from patients with acquired immune deficiency syndrome (AIDS) or pre-AIDS showed serum antibodies to type III human T-cell leukemia virus (HTLV-III) 10 to 12 weeks after transfusion. One animal also developed lymphadenopathy, transient depression of the ratio of T4 to T8 lymphocytes, and impaired blastogenic responses. No opportunistic infections occurred. Adenopathy persisted for 32 weeks, and antibody to HTLV-III persisted for at least 48 weeks. This transmission of HTLV-III by lymphocyte-poor plasma confirms the potential risk of such plasma or plasma derivatives to recipients. The susceptibility of the chimpanzee to HTLV-III infection and the ability to simulate the human lymphadenopathy syndrome in this animal makes it a valuable model for further study of AIDS.This publication has 11 references indexed in Scilit:
- Evidence for Exposure to HTLV-III in Uganda Before 1973Science, 1985
- Antibodies Reactive with Human T-Lymphotropic Retroviruses (HTLV-III) in the Serum of Patients with AIDSScience, 1984
- Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDSScience, 1984
- Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDSScience, 1984
- Transfusion-Associated AIDS: Serologic Evidence of Human T-Cell Leukemia Virus Infection of DonorsScience, 1984
- Acquired Immunodeficiency Syndrome (AIDS) Associated with TransfusionsNew England Journal of Medicine, 1984
- Acquired Immunodeficiency Syndrome: Epidemiologic, Clinical, Immunologic, and Therapeutic ConsiderationsAnnals of Internal Medicine, 1984
- Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)Science, 1983
- A Longitudinal Study of a Patient with Acquired Immunodeficiency Syndrome Using T Cell Subset AnalysisPublished by Springer Nature ,1983
- Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.Proceedings of the National Academy of Sciences, 1979