DEVELOPMENTAL ABNORMALITIES OF SKELETAL SYSTEM INDUCED BY ETHYLURETHAN IN THE RAT

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Abstract
The developmental abnormalities caused by ethylurethan were investigated in the rat embryos. The daily dose of 1.0 g/kg of ethylurethan was administered orally during the 1st (0-5th day), 2nd (6-12th day) and 3rd (13-19th day) trimester of the gestation. Further, the same dose of the compound was given at 1 or 2 days In the 2nd trimester. Maternal body weight gain and weight of living fetuses and placentae were reduced by the administration of ethylurethan during the 3rd trimester, while living litter size was markedly decreased by the treatment of dams during the 1st and 2nd trimester. The gross abnormalities such as no tall, hydrops of trunk, cleft palate, exencephaly and celosoma were observed in the offspring of the rats who received ethylurethan during the 2nd trimester. The malformations caused by ethylurethan were mainly found in the skeletal system, especially as the various malformations in the vertebrae and ribs. These skeletal abnormalities were observed with the highest frequency in the offspring of the rats treated on the 8-9th day of gestation. The dietary restrictions during the 2nd trimester did not produce the developmental abnormalities.