Effect of Starvation on Alcohol Metabolism and Hepatic Enzyme Activities in Dogs

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Abstract
Twenty experimental dogs fasted 6 days and 10 control dogs fasted 16 hrs. were injected with ethanol, 2gAg. Samples of blood were obtained 60, 150, 240, 330 minutes later. The dog was then killed with nembutal. Specimens of liver were removed, frozen, weighed and analyzed for catalase activity, ethanol oxidizing activity and nitrogen content. Ethanol concentration in the blood was determined. No marked change was found in rate of ethanol metabolism in the intact experimental animal nor in the rate of alcohol metabolism in the liver homogenate. Catalase activity per mg liver was increased following the fast.