Mus poschiavinus Y Chromosome in the C57BL/6J Murine Genome Causes Sex Reversal
- 6 August 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 217 (4559) , 535-537
- https://doi.org/10.1126/science.7089579
Abstract
When the Y chromosome from Mus poschiavinus (YPOS) is transferred onto the C57BL/6J genome, XY individuals develop as females with two ovaries, or as hermaphrodites. No XY individual develops normal testes. Although C57BL/6J-YPOS XY females are rarely fertile, most hermaphrodites with normal male genitalia sire offspring. Thus, the Mus poschiavinus Y chromosome carries a form of the Y-linked testis-determining locus different from that present in the C57BL/6J inbred strain. This gene interacts abnormally with autosomal or X-linked testis-determining loci of the CS7BL/6J genome to prevent normal testicular differentiation. Divergence of the Y-linked testis-determining gene may be involved in mammalian speciation.This publication has 8 references indexed in Scilit:
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