Duchenne muscular dystrophy

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Abstract
In carrying out a new study of nucleotide concentrations in dystrophic muscle, we utilized myosin as a reference base. In nine control vastus lateralis muscle samples, nucleotide concentrations were 105 211 (SEM) moles of adenosine triphosphate (ATP) and 446 ± 57 (SEM) moles of creatine phosphate (CP) per milligram of myosin. In seven Duchenne dystrophic vastus lateralis muscle samples, nucleotide concentrations were 127 ± 25 (SEMI nmoles of ATP and 462 ± 119 (SEM) moles of CP per milligram of myosin. The CPATP ratio of 3.6 2 0.367 from Duchenne muscle was not signiificantly different from normal, 4.32 ± 0.243 ((p p p <0.01). These studies suggest that ATP and CP concentrations are not decreased in Duchenne dystrophic muscle when expressed in relation to the amount of contractile protein.