Specific Secretion of Polypeptides from Cells Infected with Myxoma Virus

Publisher Website
Google Scholar
Abstract
The polypeptides secreted from rabbit kidney RK-13 cells infected with myxoma virus were studied. Three virus-induced polypeptides were detected. One major and 1 minor polypeptide were synthesized and secreted in the absence of virus DNA synthesis; 1 minor polypeptide was not detected in the medium under such conditions. All these polypeptides were glycosylated and 1 was sulfated. Two precipitin lines were seen in Ouchterlony tests examining medium from infected rabbit cells and using serum from rabbits convalescent from myxoma virus infections. These antigens were unrelated to the virus-specific antigens released from cells infected with vaccinia virus. No major differences were detected in comparisons between the polypeptides secreted from cells infected with virulent and relatively avirulent strains of myxoma virus.