Deletions in the constant region locus can account for switches in immunoglobulin heavy chain expression
- 1 June 1980
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 285 (5765) , 450-456
- https://doi.org/10.1038/285450a0
Abstract
Deletions spanning portions of the heavy chain constant region (CH) locus in murine plasmacytomas are revealed by hybridization with cloned immunoglobulin DNA molecules. The pattern of deletions suggests that a lymphocyte clone switches expression of CH genes by successive deletions and that the probable CH gene order is 5′ µ-γ3-γ1-γ2b-γ2a-α3′.Keywords
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