Recovery from X-ray Damage to the Lens. The Effects of Fractionated X-ray Doses Observed in Rabbit Lens Epithelium Irradiatedin vivo

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Abstract
The lens of the eye is suggested as anew system for short-term fractionation effects. Recovery has been seen between 2 X-ray doses, using the number of "broken" cells/half lens fixed and stained 14 days after the 1st X-ray dose as the biological criterion of damage. A peak-and-trough recovery pattern similar to that seen in single-cell systems was apparent, but no recovery was observed between 2 500-rad X-ray doses until they were spaced more than 6 hrs. apart; the maximum 1st "peak" of the recovery curve was seen at 6 hrs. separation between doses. The D2-D1 value approximated 200 rads; a total of 1200 rads in 2 fractions 8 hrs. apart produced virtually the same number of "broken" cells as a single dose of 1000 rads.

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