Reduced Folate Carrier Gene Silencing in Multiple Antifolate-resistant Tumor Cell Lines Is Due to a Simultaneous Loss of Function of Multiple Transcription Factors but Not Promoter Methylation
Open Access
- 1 January 2004
- journal article
- Published by Elsevier
- Vol. 279 (1) , 374-384
- https://doi.org/10.1074/jbc.m309092200
Abstract
No abstract availableKeywords
This publication has 39 references indexed in Scilit:
- Membrane Transport of FolatesPublished by Elsevier ,2003
- Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell linesBiochemical Journal, 2002
- mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR methodLeukemia, 2000
- Clustering of Mutations in the First Transmembrane Domain of the Human Reduced Folate Carrier in GW1843U89-resistant Leukemia Cells with Impaired Antifolate Transport and Augmented Folate UptakeJournal of Biological Chemistry, 2000
- Impaired Membrane Transport in Methotrexate-resistant CCRF-CEM Cells Involves Early Translation Termination and Increased Turnover of a Mutant Reduced Folate CarrierPublished by Elsevier ,1999
- A Structurally Altered Human Reduced Folate Carrier with Increased Folic Acid Transport Mediates a Novel Mechanism of Antifolate ResistancePublished by Elsevier ,1998
- The role of impaired transport in (pre)clinical resistance to methotrexate: insights on new antifolatesDrug Resistance Updates, 1998
- AG2034: a novel inhibitor of glycinamide ribonucleotide formyltransferaseInvestigational New Drugs, 1996
- Elevated dihydrofolate reductase and impaired methotrexate transport as elements in methotrexate resistance in childhood acute lymphoblastic leukemiaBlood, 1995
- Synthesis and biological activity of resolved carbon-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterinJournal of Medicinal Chemistry, 1986