Hypersensitivity to salicylazosulfapyridine: renal and hepatic toxic reactions

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Abstract
Salicylazosulfapyridine has been used for a number of years as therapy for ulcerative colitis. Reported toxicities are usually minor. This [human] case reported represents an acute allergic reaction to the drug, characterized by fever, rash, eosinophilia, nephritis and hepatitis. Resolution occurred with discontinuation of salicylazosulfapyridine. Although similar reactions have been reported with the antimicrobial sulfonamides, none has been fully described with salicylazosulfapyridine, a combination of a sulfonamide and salicylate.

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