The Use of Collagenase in the Treatment of Peyronie’s Disease

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Abstract
Purified clostridial collagenase was administered intralesionally in 31 men with Peyronie''s disease. Within 4 wk of treatment 20 patients showed an objective improvemwent. Pain was eliminated in 13 of 14 patients with this complaint at presentation within the same 4-wk period. The ability to have intercourse was restored in 3 of 4 patients with this problem. Except for a small corporeal rupture at the site of injection in 1 patient, no significant untoward effects were noted. During the mean 9.8-mo. followup 1 recurrence of bending was noted.