Effects of Adrenalectomy on Pigmentation of Hair in Rats Fed a Deficient Diet

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Abstract
Graying of the hair results in black rats fed a vit. B-complex-free diet, supplemented with thiamine, riboflavin, and pyridoxine. New hair growing in after the ablation of both adrenal glands in rats kept on such a deficient diet is again well pigmented. To determine whether the increased pigmentation was due to the lack of the medullary or cortical portion of the adrenal, the adrenals were transplanted into the kidneys. The medullary portion of the adrenal degenerated, the cortex persisted, and poorly pigmented hair grew on the animals. Thus the lack of the cortex was related to the increased pigmentation following adrenalectomy.