Studies on Immunoreactive Pancreatic Elastase 2 in Human Serum
- 1 January 1980
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 361 (1) , 633-640
- https://doi.org/10.1515/bchm2.1980.361.1.633
Abstract
A radioimmunoassy for human pancreatic elastase 2 is described. DFP-inactivated pancreatic elastase 2 is used as standard and tracer. The concentration in normal human plasma is approximately 60 .mu.g immunoreactive pancreatic elastase 2, which rises in acute pancreatitis. Pancreatic elastase 2 appears in plasma in a form with a molecular size exceeding that of the proenzyme. In vitro studies demonstrate that a complex between pancreatic elastase 2 and .alpha.1-antitrypsin arises after incubation of a mixture of pancreatic juice and plasma. Proelastase is probably bound by .alpha.1-antitrypsin after the discharge from the pancreatic gland to the extracellular tissue fluids around the gland.This publication has 13 references indexed in Scilit:
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