Reduction in Blood Volume as the Cause of Hemorrhagic Lipemia in Rabbits

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Abstract
In order to clarify the genesis of hemorrhagic lipemia rabbits were bled and the following substances were injected saline, plasma, corpuscle suspension, and a solution of a macromolecular substance. Then changes in plasma lipids and blood volume were studied once a day 3 days. Separate injections of identical amounts of plasma and of corpuscle suspension, respectively, corresponding to twice the amount of blood withdrawn, inhibited the development of hemorrhagic lipemia and increased the blood volume. However, injections of isotonic saline corresponding to twice the amount of blood withdrawn failed to inhibit the occurrence of hemorrhagic lipemia and also failed to increase the blood volume. Injections of the solution of macromolecular substance in the same amount as blood withdrawn inhibited hemorrhagic lipemia. The development of hemorrhagic lipemia in rabbits cannot be ascribed solely to bleeding, plasma removal or corpuscle removal, but is due to reduction in blood volume.