EFFECTS OF DEXTRAN, POLYVINYLPYRROLIDONE AND GAMMA GLOBULIN ON THE HYPERLIPIDEMIA OF EXPERIMENTAL NEPHROSIS*

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Abstract
The 3 day intraperitoneal administration of these substances was found to lower plasma lipid concentrations (triglyceride, total cholesterol and phospholipids) in nephrotic rats in a pattern similar to that resulting from albumin administration. Doses were sufficient to expand plasma volume, and, in general, the magnitude of plasma lipid reduction was directly related to the plasma concentration of the macromolecular substance used. Only polyvinylpyrrolidone caused any alteration in the plasma lipids of normal rats, and this was proportionally less than in the nephrotic animals. The nephrotic state of the rats was not altered, as judged by plasma albumin concentration and proteinuria. There was no demonstrable evidence that any of these compounds released lipoprotein lipase or enhanced clearing of plasma lipids by acting as acceptors of free fatty acids. The possibility that the lipid-lowering effects of these substances is related to their osmotic activity is considered.