Relationships Between Biological Activity of N-Phenylamides of Benzoylacetic Acid and Their Capacity Ratios in Reversed-Phase Systems
- 1 January 1982
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 5 (1) , 39-48
- https://doi.org/10.1080/01483918208068817
Abstract
The relationships between lipophilicity of N-phenylamides of benzylacetic acid derivatives and their biological activity were investigated. Experimental RM and k'' values for systems of the type water + methanol-octadecyl silica were determined by high performance thin layer chromatography and high performance liquid chromatography, respectively. The equations describing the activity relationships confirm the importance of hydrophobic character of the compounds in determining their pharmacological properties.This publication has 20 references indexed in Scilit:
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