Direct measurement of octanol-water partition coefficients by high-pressure liquid chromatography
- 1 May 1976
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 19 (5) , 615-619
- https://doi.org/10.1021/jm00227a008
Abstract
A technique is presented for the direct measurement of octanol-water partition coefficients by HPLC for use in lung analysis. The method involves running solutes in octanol-saturated water as the mobile phase against water-saturated octanol entrained on an inert support. Log P correlates linearly with log tc for a number of standards. The measurable range in log P (so far) is -0.03 to +3.7. A critical review of chromatographic methods in Hansch analysis is given.This publication has 2 references indexed in Scilit:
- A new form of chromatogram employing two liquid phasesBiochemical Journal, 1941
- Zur Theorie der AlkoholnarkoseNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1899