Resistance of Escherichia coli to rifampicin and sorangicin A - a comparison.
- 1 January 1990
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 43 (1) , 88-91
- https://doi.org/10.7164/antibiotics.43.88
Abstract
Sorangicin A, a macrolide polyether antibiotic and the ansamycin antibiotic rifampicin inhibit DNA-dependent RNA polymerase to a similar extent. Resistance to sorangicin A is due to a mutation in the RNA polymerase which renders the enzyme less sensitive. Parallel invetigations with rifampicin revealed partial cross-resistance, which was more marked in sorangicin A-resistance mutants than in rifampicin-resistant mutants.This publication has 3 references indexed in Scilit:
- Mapping and sequencing of mutations in the Escherichia colirpoB gene that lead to rifampicin resistancePublished by Elsevier ,2004
- The sorangicins, novel and powerful inhibitors of eubacterial RNA polymerase isolated from myxobacteria.The Journal of Antibiotics, 1987
- RNA polymerase rifampicin resistance mutations in Escherichia coli: Sequence changes and dominanceMolecular Genetics and Genomics, 1983