Pituitary Enlargement, Pituitary Failure, and Primary Hypothyroidism

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Abstract
Enlargement of the pituitary gland associated with primary hypothyroidism was observed in 2 patients. Serum thyroid-stimulating hormone (TSH) concentration and the TSH response to thyrotropin-releasing hormone were increased in both. Other pituitary function tests were subnormal in both patients, suggesting that a thyrotropin pituitary tumor was present that compromised the other pituicytes. The presence of a pituitary tumor secondary to primary hypothyroidism and resulting pituitary failure should be considered in all patients with long-standing primary hypothyroidism.