Effects of Cortisone, Hydrocortisone and AGTH on Mammary Growth and Pituitary Prolactin Content of Rats.
- 1 July 1955
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 89 (3) , 455-458
- https://doi.org/10.3181/00379727-89-21843
Abstract
Physiological saline (0.85%) or 2 mg doses of ACTH, cortisone or hydrocortisone were injected daily for 10 days into 42 intact, mature female rats. All 3 hormones elicited branching of ducts, lobule-alveolar development and secretory activity in mammary glands. This was most marked for cortisone and least for ACTH at the dose levels employed. Cortisone increased pituitary prolactin content by about 23%, hydrocortisone by about 41% and ACTH by about 71%. It is concluded that these hormones can initiate mammary development and secretion in the intact rat, but their normal role is not established.Keywords
This publication has 4 references indexed in Scilit:
- THE EFFECT OF CORTISOL UPON THE MAMMARY GLANDS1954
- EFFECT OF ADRENALECTOMY ON THE MAMMARY GLAND OF THE CASTRATED AND ESTROGEN TREATED CASTRATED MALE RAT1Endocrinology, 1947
- EFFECT OF ADRENALECTOMY ON THE LACTOGENIC HORMONE AND INITIATION OF LACTATION1,2Endocrinology, 1942
- Studies on the physiology of lactation. VI. The endocrine influences con cerned in the development and function of the mammary gland in the guinea pigJournal of Anatomy, 1937