EFFECT OF ADRENALECTOMY ON THE MAMMARY GLAND OF THE CASTRATED AND ESTROGEN TREATED CASTRATED MALE RAT1

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Abstract
In the strain of rats used, castration resulted in a reduction but not complete elimination of the alveolar development normally found in the mammary glands of adult d1 [male][male]. Adrenalectomy of castrated 6"[male] rats and maintenance on 1% saline for 10 days resulted in a complete elimination of the alveolar development, and thin atrophic ducts. Administered estrogen, although causing noticeable duct stimulation, was relatively ineffective in stimulating mammary alveolar growth in adrenalectomized, castrated rats maintained on salt, as compared to castrated rats. A possible mediatory role of the adrenal cortex in the mammary alveolar response to administered estrogen is indicated.