CUTANEOUS T-CELL LYMPHOMA-CELLS EMPLOY A RESTRICTED RANGE OF T-CELL ANTIGEN RECEPTOR VARIABLE REGION GENES
- 1 January 1990
- journal article
- research article
- Vol. 136 (1) , 17-21
Abstract
Monoclonal antibodies that recognize the proteins specified by two families of T-cell antigen receptor variable region genes were assessed as clonal markers in cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome). About 3% to 5% of tumors were expected to react with each antibody. However, 10 of 16 cases studied reacted with MAbs specific for the V.beta.8 gene family. All the positive cases were examples of the plaque or tumor stages of CTCL. None of the cases of eczematoid or premycotic CTCL showed uniform reactivity with these antibodies. Unexpected use of one particular V gene family raises the possibility that CTCL derives from a distinct subpopulation of antigen- or virus-selected T cells.This publication has 23 references indexed in Scilit:
- Vβ-Specific Stimulation of Human T Cells by Staphylococcal ToxinsScience, 1989
- The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal miceCell, 1989
- Deletion of self-reactive T cells before entry into the thymus medullaNature, 1988
- T-cell antigen receptor genes and T-cell recognitionNature, 1988
- Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigensNature, 1988
- Generation of diversity in T cell receptor repertoire specific for pigeon cytochrome c.The Journal of Experimental Medicine, 1987
- ANTIBODIES TO T CELL ANTIGEN RECEPTOR BETA CHAIN FAMILIES DETECT MONOCLONAL T CELL PROLIFERATIONThe Lancet, 1986
- Expression on human thymocytes of the idiotypic structures (Ti) from two leukemia T cell lines Jurkat and HPB‐ALLEuropean Journal of Immunology, 1986
- Molecular analysis of T cell receptor (Ti) variable region (V) gene expression. Evidence that a single Ti beta V gene family can be used in formation of V domains on phenotypically and functionally diverse T cell populations.The Journal of Experimental Medicine, 1985
- Growth of normal human T lymphocytes induced by monoclonal antibody to the T cell antigen receptorEuropean Journal of Immunology, 1985