THE GLYCOGENIC ACTIVITY OF CERTAIN CRYSTALLINE STEROIDS OF THE ADRENAL CORTEX WHEN ADMINISTERED SINGLY AND WITH CORTICAL EXTRACT TO FASTED, NORMAL AND ADRENALECTOMIZED RATS1

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Abstract
A modified Kendall assay procedure for the evaluation of glycogenic factors of the adrenal cortex is characterized in terms of regression line slope and quantitative potency. Certain important differences exist in both the slope of the regression lines and their potency in glycogenic units for the following steroids: 11-dehydrocortico-sterone, corticosterone, 11-dehydro-17-hydroxycorticosterone, 17-hydroxycorticosterone, allopregnanepentol-3,11,17,20,21, and desoxycorticosterone acetate. 17-hydroxycorticosterone was found to be the most active while desoxycorticosterone acetate and allopregnanepentol-2,11,17,20,21, were found to be totally inactive. Simultaneous adm. of corticosterone and 17-hydroxycorticosterone to the assay rats resulted in an augmentation of potency.