NATURAL MEDIATOR FOR PMN EMIGRATION IN INFLAMMATION .8. PRODUCTION OF LEUCOEGRESIN-LIKE CHEMOTACTIC FACTOR IN REVERSED PASSIVE ARTHUS REACTIONS IN RATS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 30  (4) , 521-527
Abstract
The mediation of tissue neutrophilia in the reversed passive Arthus reactions in rats was studied using extracts from skin lesions. Approximately 55% of the neutrophil chemotactic activity in the reactions exhibiting a maximal tissue neutrophilia seemed to be associated with a leucoegresin-like chemotactic factor which can be absorbed by an immunoadsorbent chromatography with anti-rat immunoglobulin G antibody. The neutrophil chemotactic activity, comparable to most of the remaining chemotactic activity, was reduced in complement-depleted conditions in which the intensity of tissue neutrophilia in the reactions was moderately decreased, suggesting a possible involvement of complement-derived chemotactic factors.