The natural mediator for PMN emigration in inflammation. V. The site of structural change in the chemotactic generation of immunoglobulin G by inflammatory SH-dependent protease.

  • 1 May 1973
    • journal article
    • Vol. 24  (5) , 791-801
Abstract
In earlier work, a chemotactic factor (leucoegresin) specific for neutrophilic polymorphonuclear (PMN) leucocytes had been isolated from the inflamed site of Arthus reactions or cutaneous burns. The substance shared common antigenic sites with IgG, and was produced in vitro from normal rabbit IgG and human IgG by a purified neutral SH-dependent protease from inflammatory tissue. A similar chemotactic factor was also produced in vitro by papain from papain-resistant IgG of rabbit, mouse and man.