A NONSPECIFIC INCREASE IN PERMEABILITY IN ESCHERICHIA COLI PRODUCED BY EDTA

1 April 1965

journal article
research article
Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences

Vol. 53 (4) , 745-750
https://doi.org/10.1073/pnas.53.4.745

Abstract

Escherichia coli, treated with ethylenediamine tetraacetic acid (EDTA), under certain conditions becomes permeable to several unrelated molecules to which it is otherwise impermeable. This increased permeability explains the sensitivity of such preparations to the antibiotic actinomycin, which is normally ineffective against E. coli. Such cells grow at a normal rate despite this impairment of a permeability barrier.

Keywords

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