Molecular Dissection of the Inhibitor Binding Pocket of Mitotic Kinesin Eg5 Reveals Mutants that Confer Resistance to Antimitotic Agents
- 7 July 2006
- journal article
- Published by Elsevier in Journal of Molecular Biology
- Vol. 360 (2) , 360-376
- https://doi.org/10.1016/j.jmb.2006.04.062
Abstract
No abstract availableKeywords
This publication has 37 references indexed in Scilit:
- Development and Biological Evaluation of Potent and Specific Inhibitors of Mitotic Kinesin Eg5ChemBioChem, 2005
- The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinksNature, 2005
- Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSPBioorganic & Medicinal Chemistry Letters, 2005
- Mechanism of Inhibition of Human KSP by Monastrol: Insights from Kinetic Analysis and the Effect of Ionic Strength on KSP InhibitionBiochemistry, 2004
- Monastrol stabilises an attached low-friction mode of Eg5Current Biology, 2004
- Hydrogen/Deuterium Exchange Mass Spectrometry for Investigating Protein-Ligand InteractionsASSAY and Drug Development Technologies, 2004
- Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based ScreenScience, 1999
- A bipolar kinesinNature, 1996
- Mass Spectrometric Determination of Isotopic Exchange Rates of Amide Hydrogens Located on the Surfaces of ProteinsAnalytical Chemistry, 1996
- Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivoPublished by Elsevier ,1995