Renal Lipid Composition of Choline-deficient Rats

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Abstract
Three groups of weanling male rats of the Sprague-Dawley strain were used in a study of the changes in lipid composition between normal kidneys and severely hemorrhagic kidneys from choline-deficient rats. A semipurified diet, with and without choline supplement, and a laboratory ration diet were fed for 11 to 14 days. The fatty acid composition of the renal lipids from these animals was determined by gas-liquid chromatography. The fatty acid patterns of the total lipids from severely hemorrhagic kidneys showed a striking decrease in the relative amounts of linoleic and arachidonic acids when compared with values obtained with control animals. Changes in the fatty acid composition of the renal phospholipids accounted for much of the difference observed in the total lipids. The values obtained for kidneys with less severe lesions were intermediate between the extremes noted in normal and severely affected kidneys. The fatty acid changes in the abnormal kidneys appear to be related to the severity of the syndrome.

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