Urinary δ-Aminolevulinic Acid as a Biological Indicator throughout Penicillamine Therapy in Lead Intoxication
- 31 October 1978
- journal article
- research article
- Published by Taylor & Francis in Archives of environmental health
- Vol. 33 (6) , 308-313
- https://doi.org/10.1080/00039896.1978.10667353
Abstract
A group of 121 patients with occupational lead exposure was studied. Saturnism was confirmed in 42 of them. Patients were given D-penicillamine in doses of 0.75 and 1.5 g/day. Urinary δ-aminolevulinic acid was selected as a toxicity biological indicator; its concentrations were quantified daily during therapy. Urinary δ-aminolevulinic acid is considered a good biological indicator throughout penicillamine therapy and also in the detection of lead intoxication. Likewise, the chelating test is considered an excellent method to confirm the diagnosis of lead poisoning.This publication has 17 references indexed in Scilit:
- Dose-effect and dose-response relationships for lead in childrenThe Journal of Pediatrics, 1975
- Lead poisoning with low blood lead levelsPublished by Oxford University Press (OUP) ,1974
- Oral penicillamine therapy for chronic lead poisoning in childrenThe Journal of Pediatrics, 1973
- The effects of d-penicillamine on the tissue distribution and excretion of leadToxicology and Applied Pharmacology, 1973
- Urinary excretion of delta aminolevulinic acid after discontinuance of therapy for lead poisoning: A test for adequacy of therapyThe Journal of Pediatrics, 1972
- Lead Concentration Found in Human Blood in Association With Lead ColicArchives of environmental health, 1971
- Biochemical Responses to Provocative Chelation by Edetate Disodium CalciumArchives of environmental health, 1971
- Interlaboratory Evaluation of the Reliability of Blood Lead AnalysesAihaj Journal, 1970
- The use of chelating agents in the treatment of acute and chronic lead intoxication in childhoodThe Journal of Pediatrics, 1968
- Penicillamine as Lead-chelating Substance in ManBMJ, 1962