Stereochemical features of 1,4‐benzodiazepin‐2‐ones bound to human serum albumin: Difference CD and UV studies
- 1 January 1990
- Vol. 2 (3) , 167-174
- https://doi.org/10.1002/chir.530020308
Abstract
The stereochemistry of an achiral (Diazepam) and two chiral (3‐methyl and 3‐succinyloxy substituted) 1,4‐benzodiazepin‐2‐ones interacting with human serum albumin (HSA) has been investigated by making use of difference absorption (UV) and circular dichroism (CD) spectroscopies. Evidence is obtained for a higher affinity with HSA for one of the two possible conformations of the seven‐membered benzodiazepine ring. The red shift revealed by the absorption difference spectrum between the free and the bound drug accounts for the CD difference spectra observed.Keywords
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