Studying the pathogenesis of BCR–ABL+ leukemia in mice
Open Access
- 9 December 2002
- journal article
- review article
- Published by Springer Nature in Oncogene
- Vol. 21 (56) , 8643-8651
- https://doi.org/10.1038/sj.onc.1206091
Abstract
Animal models of BCR-ABL+ leukemias have provided important new knowledge about the molecular pathophysiology of these diseases, and answered questions that are difficult or impossible to address using BCR-ABL-expressing cell lines or primary Ph+ leukemia samples from patients. The power of mouse models lies in their ability to recapitulate precisely the phenotypes of BCR-ABL+ leukemias in vivo, but this comes at the price of significant complexity. Here I review recent studies of leukemias induced in mice by BCR-ABL with an emphasis on the intricate nature of these diseases and the need for careful pathological and molecular analysis.Keywords
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