Voltage‐clamp analysis of peptidergic slow depolarizations in bullfrog sympathetic ganglion cells.

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Abstract
The membrane currents during the late slow excitatory post-synaptic potential (late slow epsc) and LHRH-induced depolarization of nicotinized and atropinized bullfrog lumbar sympathetic ganglion cells were studied with voltage-clamp methods. Two types of late slow epsc were observed. The Type I response was associated with a decreased conductance and was depressed by membrane hyperpolarization. The Type II response was accompanied by an increase conductance and was augmented by membrane hyperpolarization. LHRH also induced 2 types of responses. The nature of the LHRH-induced current and the late slow epsc in each neuron was similar, if not identical. The Type I response appeared to be produced primarily by a suppression of the M current and partially by a depression of the resting K+ conductance. The Type II response is probably due to an increased conductance to Na+ or Na+ and some other cations.