Purinoceptors are involved in the induction of an osmolyte permeability in malaria‐infected and oxidized human erythrocytes

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Abstract
SPECIFIC AIMSThe intraerythrocytic development of P. falciparum induces the so-called new permeability pathways (NPP) that appear in the membrane of the parasitized red blood cells (RBCs). Functionally, the NPP are organic osmolyte and anion channels that supply the parasite with nutrients and dispose of parasite-derived waste products. Until now, the signaling cascades that trigger the increase in the plasma membrane permeability of the host RBC have been ill defined. P. falciparum infection has been demonstrated to confer a high oxidative stress on the host RBC and experimental oxidation of noninfected RBCs induces membrane permeabilities similar to the infection-induced NPP. Physiologically, the NPP contribute to the regulatory volume decrease (RVD) of the volume-stressed host erythrocyte. RVD in nucleated cells has been demonstrated to employ ATP release and autocrine purinergic signaling. Therefore, the present work tested for autocrine purinoceptor signaling in human RBCs during induction of the NPP...
Funding Information
  • Deutsche Forschungsgemeinschaft (La 315/11-1, 11-2)