Papulacandins - The relationship between chemical structure and effect on glucan synthesis in yeast.

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Abstract
Papulacandin B inhibited glucan biosynthesis in cells of Saccharomyces cerevisiae and Candida albicans. Biological studies with a series of papulacandin derivatives showed that the short fatty acid chain and the galactose residue are not required for activity at the target site; they can affect penetration. The long fatty acid residue was essential for biological activity.