The storage products in genetic and swainsonine-induced human mannosidosis
- 1 December 1983
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 215 (3) , 693-696
- https://doi.org/10.1042/bj2150693
Abstract
Swainsonine induces the accumulation of mannose-rich oligosaccharides in human fibroblasts. The composition of the storage products shows that swainsonine completely inhibits lysosomal alpha-D-mannosidase and alters processing of glycoproteins by inhibiting Golgi alpha-D-mannosidase II. Comparison of the storage products in genetic and swainsonine-induced mannosidosis suggests that human fibroblasts contain a lysosomal alpha-D-mannosidase that is unaffected in genetic mannosidosis.Keywords
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