A Comparison of Dextran and Oxypolygelatin in the Treatment of Hemorrhagic Hypotension

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Abstract
In/standardized hemorrhagic hypotension 22% dextran-treated dogs died as compared with 33% for oxypolygelatin and 85% for untreated controls. With both these agents blood pressure rises more rapidly and to higher levels than with saline. Dextran expands blood volume more and for a longer time than oxypolygelatin or dog plasma. Dextran is better than oxypolygelatin for restoration of glomerular filtration and renal plasma flow. Dextran draws about twice as much fluid from interstitial spaces as does oxypolygelatin. Postmortems were negative for both substances.