Elevated Thymidine Phosphorylase Activity in the Plasma and Ascitic Fluids of Tumor-Bearing Animals
- 1 February 1978
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 157 (2) , 262-267
- https://doi.org/10.3181/00379727-157-40034
Abstract
Activity of thymidine (TdR) phosphorylase (EC 2.4.2.4; TdR: orthophosphate deoxyribosyltransferase) in the plasma of healthy and tumor-bearing mice and rats was evaluated in comparative studies. Increased enzyme activity was recorded in 9 of 11 tumor models tested and highest values were obtained for mice with lymphoid or myeloid leukemia. Heightened activity of this TdR-degrading enzyme was observed in the plasma of mice bearing 3 of 4 solid tumors. Elevated TdR phosphorylase activity was also identified in the peritoneal exudate fluids in each of 4 groups of animals carrying ascites-producing tumors.This publication has 1 reference indexed in Scilit:
- Enzymology of Cancer CellsNew England Journal of Medicine, 1977