Effects of .BETA.-endorphin, thyrotropin-releasing hormone and cholecystokinin on body shaking behavior in rats.

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Abstract
Effects of intracerebroventricular administration of .beta.-endorphin, TRH, cholecystokinin octapeptide (CCK-8), non-sulfated CCK-8 (CCK-8-NS) and caerulein on body shaking behavior were observed in rats. CCK-8 and its related peptides produced only a small increase in the number of body shakes, while TRH had the striking effect of stimulating body shakes, this increase being markedly suppressed by simultaneous administration of .beta.-endorphin. The suppressive effect of .beta.-endorphin on TRH-induced body shakes was antagonized by simultaneous administration of caerulein and CCK-8. The body shakes induced by ice-water immersion were also reduced by .beta.-endorphin, this .beta.-endorphin effect being partly antagonized by caerulein and CCK-8.