EFFECT OF ANTIBODY AVIDITY ON THE INDUCTION OF RENAL INJURY IN ANTI-GLOMERULAR BASEMENT-MEMBRANE NEPHRITIS
- 1 January 1978
- journal article
- research article
- Vol. 59 (6) , 624-629
Abstract
Antibodies to glomerular basement membrane (GBM) of the rat could be fractionated according to their avidity by elution from trypsin-digested GBM (bound to Sepharose) with increasing concentrations of KSCN. The percentage of kidney-fixing antibody in each fraction and the degree of proteinuria induced as determined 24 h after injection increased with the avidity of the antibody fraction when equal doses were administered.This publication has 13 references indexed in Scilit:
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