Cutting Edge: DNA Polymerases μ and λ Are Dispensable for Ig Gene Hypermutation
- 15 April 2002
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 168 (8) , 3702-3706
- https://doi.org/10.4049/jimmunol.168.8.3702
Abstract
Mutations arising in Ig V genes during an immune response are most likely introduced by one or several error-prone DNA polymerases. Many of the recently described nonreplicative DNA polymerases have an intrinsic fidelity compatible with such an activity, the strongest candidates being polymerase (pol) η, pol ι, pol ζ, and pol μ. We report in this work that mice inactivated for either of the two polymerases related to pol β (i.e., pol μ and pol λ) are viable and fertile and display a normal hypermutation pattern.Keywords
This publication has 25 references indexed in Scilit:
- Ig gene hypermutation: A mechanism is duePublished by Elsevier ,2002
- Emerging links between hypermutation of antibody genes and DNA polymerasesNature Reviews Immunology, 2001
- Highly Frequent Frameshift DNA Synthesis by Human DNA Polymerase μMolecular and Cellular Biology, 2001
- Identification of an Intrinsic 5′-Deoxyribose-5-phosphate Lyase Activity in Human DNA Polymerase λJournal of Biological Chemistry, 2001
- Identification and Characterization of Human DNA Polymerase β2, a DNA Polymerase β-Related EnzymePublished by Elsevier ,2000
- Two novel human and mouse DNA polymerases of the polX familyNucleic Acids Research, 2000
- DNA polymerase lambda (Pol λ), a novel eukaryotic DNA polymerase with a potential role in meiosis 1 1Edited by M. YanivJournal of Molecular Biology, 2000
- Functional Analysis of the Amino-terminal 8-kDa Domain of DNA Polymerase β as Revealed by Site-directed MutagenesisJournal of Biological Chemistry, 1998
- The Igκ 3′ Enhancer Influences the Ratio of Igκ versus Igλ B LymphocytesImmunity, 1996
- Origin of Antibody VariationNature, 1966