Effect of Feeding Pyridine Derivatives to Young Rats on a High Protein Diet

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Abstract
The effect of the ingestion of 15 different pyridine derivatives upon immature rats on a high protein diet is described. None of the N-methyl derivatives had any appreciable influence on either the fat content or the absolute liver wt. 7-Picoline, nicotinic acid, and nicotinamide produced slight increase in liver fat and [beta]-picoline and coramine produced significant increases. In the case of [beta]-picoline and coramine the increase in fat could be prevented by the inclusion of 1.2% methionine or 0.5% choline, but these supplements did not prevent the great increase in wt. of the fat-free liver produced by coramine or the growth inhibition which followed the admn. of [beta]-picoline or coramine.

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