Seminoma in Klinefelter's syndrome with 47 XXY, 15s+ karyotype
- 1 May 1977
- Vol. 39 (5) , 2041-2047
- https://doi.org/10.1002/1097-0142(197705)39:5<2041::aid-cncr2820390521>3.0.co;2-x
Abstract
A 32-year-old man was found to have seminoma of the right testis which had been subjected to orchiopexy for cryptorchism 14 years earlier. The left testis was small and firm, and the patient was further studied for hypogonadism. Chromosome analysis revealed a karyotype of 47, XXY, 15s+ with an extra X chromosome and enlarged and fluorescent satellites on chromosome 15. The satellites were also found in the mother as well as in two sisters and one brother out of his four siblings. Endocrine studies, histological pictures of the biopsied left testis and dermatoglyphic analysis were compatible with Klinefelter's syndrome. To our knowledge this is the first reported case of seminoma associated with the syndrome. Several implications are discussed for the rare occurrence of a germinal cell tumor in Klinefelter's syndrome.This publication has 17 references indexed in Scilit:
- Effects of Depot Testosterone Therapy on Serum Levels of Luteinizing Hormone and Follicle-Stimulating Hormone in Patients with Klinefelter's Syndrome and Hypogonadotropic EunuchoidismJournal of Clinical Endocrinology & Metabolism, 1974
- Klinefelter Syndrome and CancerJAMA, 1974
- Antenatal genetic diagnosis in a kindred with a 15p+ chromosomeClinical Genetics, 1973
- Y to X Translocation in a Woman With Reproductive FailureJAMA, 1973
- Responses of Serum Luteinizing Hormone and Follicle-Stimulating Hormone Levels to Synthetic Luteinizing Hormone-Releasing Hormone (LH-RH) in Various Forms of Testicular DisordersJournal of Clinical Endocrinology & Metabolism, 1973
- Multiple primary tumors including bilateral breast cancers in a man with Klinefelter's syndromeCancer, 1971
- THE MECHANISMS INVOLVED IN TESTICULAR DEGENERATION IN MANActa Endocrinologica, 1967
- AUTOIMMUNITY IN GONADAL DYSGENESIS AND KLINEFELTER'S SYNDROMEThe Lancet, 1967
- Carcinoma of Male Breast in Association with the Klinefelter SyndromeBMJ, 1965
- Cytogenetics of Down’s Syndrome (Mongolism) I. Data on a Consecutive Series of Patients Referred for Genetic Counselling and DiagnosisCytogenetic and Genome Research, 1965