Effects of ethanol and inhibitors of its metabolism on the circulating levels of Met-enkephalin in greyhounds

Abstract
The mechanisms involved in the release of Metenkephalin-like immunoreactivity (MLI) into the circulation following oral administration of ethanol and chlorpropamide were investigated in dogs. The origin of plasma MLI and the sites where it may be metabolized were also studied. Moreover, the molecular nature of circulating MLI was characterized. In conscious animals oral administration of ethanol (0·15 ml/kg) led to a significant (PPPJournal of Endocrinology (1989) 120, 473–480