The Recovery of Lethally Irradiated Dogs Given Infusions of Autologous Leukocytes Preserved at -80 C
Open Access
- 1 January 1964
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 23 (1) , 38-43
- https://doi.org/10.1182/blood.v23.1.38.38
Abstract
Nine normal mongrel dogs were exposed to 1200 r whole-body irradiation at 4 to 5 r per minute. They were then given intravenous infusions of 2.12 to 20 x 109 autologous leukocytes that had been previously stored at -80 C. in 10 per cent dimethyl-sulfoxide. Three dogs survived with delayed but complete hematopoietic recovery. Three showed beginning marrow regeneration but died within 3-4 weeks of irradiation. Three given less than 6 x 109 cells died within 21 days. The number of leukocytes infused was critical since there was no survivor among the dogs receiving less than 9 x 109 cells. It is concluded that peripheral blood contains primitive cells capable of repopulating marrow spaces and restoring marrow function.Keywords
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