Plant‐derived diterpene esters enhance HTLV‐I‐induced colony formation of lymphocytes in co‐culture

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Abstract
The addition to culture dishes of 10–50 ng/ml of the essential diterpene ester of Sapium sebiferum, 12‐O‐hexadecanoylphorbol‐13‐acetate (HPA), increased colony formation of normal peripheral blood lymphocytes co‐cultured with γ‐irradiated HTLV‐1‐producing HUT102 cells. The cells in the stimulated colonies showed an approximately 3‐fold increase in the expression of interleukin‐2 (IL‐2) receptors and a 1.5‐to 2.0‐fold increase in human T‐lymphotropic virus type‐I (HTLV‐I) p19‐positive cells. This biological potency was analogous to that induced by the most potent tumor promoter 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) and stronger than that of 12‐O‐hexade‐canoyl‐16‐hydroxyphorbol‐13‐acetate (HHPA) isolated from Aleurites fordii.

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