HORMONE SENSITIVE GENE-EXPRESSION IN BREAST-TUMORS

  • 1 January 1990
    • journal article
    • research article
    • Vol. 10  (1) , 185-188
Abstract
The expression of genes specifically induced by estrogens (pS2), prolactin (PIP) or progestins (Pg8) was measured in primary breast tumours. A highly augmented ps2 gene expression was evident in 55% of estrogen receptors (ER)+, progesterone receptor (PR) + tumours but was absent in ER- PR- tumours. There was no clear cut correlation between augmented levels of PIP and Pg8 mRNAs in tumours and ER and PR status. Tumours from premenopausal patients were more likely to contain high levels of Pg8 mRNA (P < 0.038), whereas tumours from postmenopausal patients tended to have augmented levels of PIP mRNa (P < 0.053).