Iodide and Negative Anion Gap

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Abstract
To the Editor: We recently took care of a patient with an extremely high serum chloride concentration and a negative anion gap. We considered this abnormality secondary to high serum iodide, a cause not mentioned in recent reviews.1 , 2 The patient was a 56-year-old man who had been intermittently followed for multiple problems, including renal insufficiency and nephrotic syndrome secondary to membranoproliferative glomerulonephritis, hypertension and asthmatic bronchitis. Severe anasarca refractory to all the usual modes of therapy had recently developed, thus necessitating peritoneal dialysis for fluid removal. On his most recent hospitalization, the patient was admitted for a 20-kg weight gain . . .

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