Defective Modulation of Complement in Crohn's Disease: C3b Opsonization of Zymosan by the Alternative Pathway
- 1 January 1985
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Gastroenterology
- Vol. 20 (7) , 883-886
- https://doi.org/10.3109/00365528509088840
Abstract
Opsonization of zymosan by plasma complement was studied in 12 consecutive patients with untreated, well-established Crohn''s disease and in 12 healthy volunteers. Binding of C3b to zymosan was markedly increased in patients with Crohn''s disease during the first 30 min of the alternative pathway reaction, whereas consumption of the native C3 protein was within the normal range in all patients. Our results are consistent with a decreased capacity for degradation of activated C3, C3b by the I-H factor inactivator system. This immunologic abnormality may contribute to a chronic activation of the complement sequence, previously demonstrated in Crohn''s disease, and to a release of split products of inflammation-promoting character.This publication has 13 references indexed in Scilit:
- Hypercatabolism of Complement in Crohn's Disease-Assessment of Circulating C3cActa Medica Scandinavica, 2009
- Subnormal activation of phagocytes by complement in chronic inflammatory bowel disease? Neutrophil chemotaxis to complement split product C5a.Gut, 1984
- A single step immunoelectrophoresis method for the quantitation of complement C3c in biological fluidsJournal of Immunological Methods, 1983
- Defective release of C5a related chemo-attractant activity from complement in Crohn's disease.Gut, 1983
- Leucocyte function in Crohn's disease. Studies on mobilisation using a quantitative skin window technique and on the function of circulating polymorphonuclear leucocytes in vitro.Gut, 1982
- Abnormalities of neutrophil function do not cause the migration defect in Crohn's disease.Gut, 1981
- In vitro studies on cellular and humoral chemotaxis in Crohn's disease using the under agarose gel technique.Gut, 1981
- Complement inhibitors and immunoconglutinins in ulcerative colitis and Crohn's disease.Gut, 1980
- NEUTROPHIL DYSFUNCTION IN CROHN'S DISEASEThe Lancet, 1976
- In vivo activation of C3 revealed by crossed immunoelectrophoresis as a parameter of immunological activity in diseaseClinica Chimica Acta; International Journal of Clinical Chemistry, 1975