COMPLEMENT AS A FACTOR IN ARTERIOSCLEROSIS

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Abstract
Massive doses of vitamin‐D in a few days provoke heavy clinical symptoms and histologically significant vascular changes, particularly in the aorta, coronary arteries and renal vessels of rats. Intravenous administration of zymosan completely cuts out these effects. Our conclusion is, therefore, that inactivation of circulating complement inhibits the vitamin‐D produced arterial lesions. We suggest that complement not only is an important factor in arteriosclerosis produced by vitamin‐D poisoning, but find it conceivable that it may play a similar key role in human aortic and coronary sclerosis.